Blar i forfatter "Kjellin, Midori"

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    • Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals 

      Howe, Anita Y.M.; Rodrigo, Chaturaka; Cunningham, Evan B.; Douglas, Mark W.; Dietz, Julia; Grebely, Jason; Popping, Stephanie; Sfalcin, Javier Alejandro; Parczewski, Milosz; Sarrazin, Christoph; de Salazar, Adolfo; Fuentes, Ana; Sayan, Murat; Quer, Josep; Kjellin, Midori; Kileng, Hege; Mor, Orna; Lennerstrand, Johan; Fourati, Slim; Di Maio, Velia Chiara; Chulanov, Vladimir; Pawlotsky, Jean-Michel; Harrigan, P. Richard; Ceccherini-Silberstein, Francesca; Garcia, Federico (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-24)
      Background & Aims: Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment options and risking onward resistant virus transmission. In this study, we evaluated RAS prevalence and distribution, including novel NS5A RASs and ...

    • Effect of the baseline Y93H resistance-associated substitution in HCV genotype 3 for direct-acting antiviral treatment: real-life experience from a multicenter study in Sweden and Norway 

      Kjellin, Midori; Kileng, Hege; Akaberi, Dario; Palanisamy, Navaneethan; Duberg, Ann-Sofi; Danielsson, Astrid; Kristiansen, Magnhild Gangsøy; Nöjd, Johan Edvin; Aleman, Soo; Gutteberg, Tore Jarl; Goll, Rasmus; Lannergård, Anders; Lennerstrand, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-19)
      <i>Background</i>: The NS5A resistance-associated substitution (RAS) Y93H is found quite frequently (5–10%) at baseline in direct-acting antiviral agents (DAA) treatment-naïve genotype (GT) 3a patients when studied by the population-sequencing method (cut-off 20%). This RAS may impair HCV DAA treatment response, since it possesses a high fold <i>in vitro</i> resistance to daclatasvir (DCV) and ...

    • Personalized treatment of hepatitis C genotype 1a in Norway and Sweden 2014-2016: a study of treatment outcome in patients with or without resistance-based DAA-therapy 

      Kileng, Hege; Kjellin, Midori; Akaberi, Dario; Bergfors, Assar; Duberg, Ann-Sofi; Wesslen, Lars; Danielsson, Astrid; Kristiansen, Magnhild Gangsøy; Gutteberg, Tore Jarl; Goll, Rasmus; Lannergård, Anders; Lennerstrand, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-05)
      <i>Objectives</i>: Resistance-associated substitutions (RASs) may impair treatment response to direct-acting antivirals (DAA) in hepatitis C virus (HCV) treatment. We investigated the effects of baseline NS3-RASs (Q80K and R155K) and clinically relevant NS5A-RASs in patients with HCV genotype (GT) 1a infection on treatment outcome, with or without resistance-based DAA-treatment. This multi-center ...